Pancreatic neuroendocrine tumours – new therapeutic concepts
نویسندگان
چکیده
منابع مشابه
Somatostatin receptors in gastroentero-pancreatic neuroendocrine tumours.
Five somatostatin receptor (sst) subtype genes, sst(1), sst(2), sst(3), sst(4) and sst(5), have been cloned and characterised. The five sst subtypes all bind natural somatostatin-14 and somatostatin-28 with high affinity. Endocrine pancreatic and endocrine digestive tract tumours also express multiple sst subtypes, but sst(2) predominance is generally found. However, there is considerable varia...
متن کاملWhole-genome landscape of pancreatic neuroendocrine tumours
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this increase is creating challenges for clinical management. We performed whole-genome sequencing of 102 primary PanNETs and defined the genomic events that characterize their pathogenesis. Here we describe the mutational signatures they harbour, including a deficiency in G...
متن کاملAcute pancreatitis secondary to pancreatic neuroendocrine tumours.
CONTEXT Pancreatic neoplasms are an uncommon aetiology of acute pancreatitis. Pancreatic neuroendocrine tumours are a rare subgroup of pancreatic neoplasms. CASE REPORT We report on three patients having acute pancreatitis secondary to pancreatic neuroendocrine tumours, one of them with severe pancreatitis, and review the published cases up to now. Only 22 patients with acute pancreatitis sec...
متن کاملDiagnostic/therapeutic management of pancreatic neuroendocrine tumours associated with MEN 1 syndrome.
1. Yue WM, Brodner W, Highland TR. Long-term results after anterior cervical discectomy and fusion with allograft and plating: a 5 to 11-year radiologic and clinical follow-up study. Spine (Phila Pa 1976). 2005;30:2138–44. 2. Baron EM, Soliman AM, Gaughan JP, Simpson L, Young WF. Dysphagia, hoarseness, and unilateral true vocal fold motion impairment following anterior cervical diskectomy and f...
متن کاملTargeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours
Inactivating MEN1 mutations are the most common genetic defects present in sporadic and inherited pancreatic neuroendocrine tumours (PNETs). The lack of interventional therapies prompts us to explore the therapeutic approach of targeting β-catenin signalling in MEN1-mutant PNETs. Here we show the MEN1-encoded scaffold protein menin regulates phosphorylation of β-catenin. β-catenin signalling is...
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ژورنال
عنوان ژورنال: memo - Magazine of European Medical Oncology
سال: 2012
ISSN: 1865-5041,1865-5076
DOI: 10.1007/s12254-012-0339-y